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Glutamate, as a primary excitatory neurotransmitter, can induce a substantial influx of calcium ions into the cell upon binding to NMDAR, leading to calcium overload

According to FDA prescribing information, these include: Nausea (occurring in 1544% of patients depending on formulation and dose) Vomiting (524% of patients) Diarrhea (830% of patients) Abdominal pain (511% of patients) Constipation (324% of patients) These gastrointestinal symptoms typically emerge during dose escalation and often diminish over time as physiological tolerance develops

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BCBSTX typically covers PHPs, making this level of care easier to access

10.1111/dom.16364 101 TianS.LeiY.ZhaoF.CheJ.WuY.LeiP.et al (2024)